Gel Scaffolds of BMP-2-Binding Peptide Amphiphile Nanofibers for Spinal Arthrodesis
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چکیده
منابع مشابه
Self-assembly and mineralization of peptide-amphiphile nanofibers.
We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite materia...
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1. International Center for Young Scientists, National Institute for Materials Science, Nano and Biomaterials Research Building, Tsukuba, Ibaraki, JAPAN 2. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University Hospital, Kyoto, JAPAN 3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA 4. Medicin...
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Twelve derivatives of peptide-amphiphile molecules, designed to self-assemble into nanofibers, are described. The scope of amino acid selection and alkyl tail modification in the peptide-amphiphile molecules are investigated, yielding nanofibers varying in morphology, surface chemistry, and potential bioactivity. The results demonstrate the chemically versatile nature of this supramolecular sys...
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ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2014
ISSN: 2192-2640
DOI: 10.1002/adhm.201400129